WG on Eosinophilic Esophagitis

Board 2019-2021

IG Chair Antonella Cianferoni USA

IG Secretary Dagmar Simon Switzerland

Past Chair & Board Member Ingrid Terreehorst Netherlands

Board Member Emilia Vassilipoulou Greece

Board Member Pablo Torres Equador

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About Eosinophilic Esophagitis

Eosinophilic esophagitis (EoE) is a chronic, immune-mediated inflammatory condition of the esophagus. It may occur in all ages with characteristic symptoms of esophageal dysfunction, while diagnosis is confirmed by endoscopic findings and a significant esophageal eosinophilia. In adults, it is associated with difficulty in swallowing, food impaction, chest pain and stricture formation in the esophagus. In children, symptoms include vomiting and regurgitation, feeding disorders and oral aversion, food impaction and a general failure to thrive. Endoscopic findings that might signal eosinophilic esophagitis include rings, stricture, furrow or straight lines, white spots, and a small-caliber esophagus. However, endoscopy in patients with EoE may result without pathological findings. The etiology of EoE is not known, however atopy is a risk factor. Most patients with EoE are allergic to inhalants and food allergens. But in 30% of patients, endoscopic exams turn up normal. Treatment of EoE is mainly based on dietary restrictions and antiinflamatory medications, while endoscopical interventions are necessary in severe cases of esophageal stenosis. The EoE WG intents to inform and update EAACI members on this diseases, to offer educational tools and organize educational meetings on EoE.

 

Eosinophilic esophagitis is characterized by a non-IgE mediated food hypersensitivity
D Simon, et al. 
https://onlinelibrary.wiley.com/doi/full/10.1111/all.12846

Microbiome and its impact on gastrointestinal atopy
AB Muir et al. 
https://onlinelibrary.wiley.com/doi/10.1111/all.12943

Diagnosis and management of non-IgE gastrointestinal allergies in breastfed infants - an EAACI position paper
R Meyer et al. 
https://onlinelibrary.wiley.com/doi/10.1111/all.13947

Eosinophilic esophagitis phenotypes: Ready for prime time?
D Atkins et al. 
https://onlinelibrary.wiley.com/doi/10.1111/pai.12715