- Better diagnosis: more patients with positivity to allergological tests
- Modern lifestyle: increased exposure to household irritants
- Reduced incidence of infections with a switch of T cells from Th1 to Th2
- Increased mobility with consequent exposure to new allergens
- Increased indoor and outdoor airborne pollutants.
Allergic respiratory diseases are known to be genetically determined. Therefore, the dissection of the relative contribution of environmental and genetic factors will provide a deeper understanding of the pathophysiology underlying the trends in allergic diseases.
Drastic environmental modifications have been targeted as the mean culprit for the rise. However, to induce an atopic- allergic sensitization, the environmental factors act in this way