The first book to provide a truly comprehensive perspective
Immune-mediated reactions with exanthems, fever and internal organ involvement are a challenge to research: different drugs can induce a variety of clinical symptoms through multiple mechanisms of drug-host interaction.
Approaching the phenomenon of drug hypersensitivity in a comprehensive manner, this book aims to be of immense value to allergologists, dermatologists and anyone prescribing medication, as well as to scientists in the pharmaceutical industry challenged by the economic effects of failures in drug development or drug removal from the market. Besides epidemiological aspects, it addresses the immunological mechanisms underlying these complicated reactions which go far beyond the IgE-mediated drug allergies also considered in the book. Furthermore, the book covers clinical manifestations and new diagnostic methods, and introduces some recently established animal models. Well-accepted and also completely new concepts are presented and discussed in detail.
Elucidating the mechanisms of drug hypersensitivity will not only help to identify patients at risk but will also provide novel insights into the pathophysiology of numerous immune-mediated diseases.
Book Contents: The chapters entailed refer to:
Epidemiology of Drug Allergies, Causes of Drug Hypersensitivity
Epidemiology and of Severe Cutaneous Adverse Reactions to Drugs, Pathomechanisms, Genetics and Animal Models, Chemical-Induced Contact, Hypersensitivity in the Mouse Model, Lessons from Nickel Hypersensitivity, Drugs as Haptens, Antigens, and Immunogens, The p-i Concept, Tolerance Mechanisms to Small Molecular Compounds , HIV and Drug Hypersensitivity, Abacavir Hypersensitivity, Genetics of Severe Drug Hypersensitivity Reactions in Han Chinese, Nevirapine Hypersensitivity, Animal Models of Toxic Epidermal Necrolysis, Non-Clinical Testing Approaches for Drug Development, Adverse Side Effects to Biological Agents, Clinical Manifestations, Drug Hypersensitivity Reactions, Urticaria and Anaphylaxis due to Betalactams, Perioperative Anaphylaxis, IgE-Mediated Allergy to Pyrazolones, Quinolones and Other Non- -Lactam Antibiotics, Hypersensitivity Reactions to Iodinated Contrast Media: An Update, Maculopapular Drug Eruptions, Drug-Induced Hypersensitivity Syndrome and Viral Reactivation, Clinic and Pathogenesis of Severe Bullous Skin Reactions: Stevens-Johnson Syndrome, Toxic Epidermal Necrolysis, Drug Allergic Liver Injury, Drug-Induced Interstitial Nephritis, Blood Dyscrasias Caused by Hypersensitivity to Drugs, Allergy and Pseudoallergy to Drugs and Vaccines in Children, Hypersensitivity to Aspirin and Other NSAIDs, Clinical Presentation and Management, Approach to the Patient with a Drug Hypersensitivity Reaction, Place of Drug Skin Tests in Investigating Systemic Cutaneous Drug Reactions, In vitro Tests of T-Cell-Mediated Drug Hypersensitivity, Basophil Activation Tests, Desensitization with Antibiotics, Drug Desensitization in Oncology.
Author: W.J. Pichler, Bern