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ABOUT ALLERGIES
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Chairman: Barbara Bohle, PhD

656Current position:

University Dozent at the Department of Pathophysiology, Center for Physiology and Pathophysiology, Medical University of Vienna, Austria

Group Leader at the Department of Pathophysiology, Center for Physiology and Pathophysiology, Medical University of Vienna, Austria.

 

 

 

 

Training Milestones:

  • 1987 Academy for Medical and Technical Assistants, Vienna
  • 1988-2000 Medical Technical Assistant at the Institute of General and Experimental Pathology, Vienna
  • 1992-1997 Undergraduate study "Food- and Biotechnology" at the University of Natural Resources and Applied Life Sciences, Vienna
  • 1997-2000 PhD thesis at the University of Natural Resources and Applied Life Sciences, Vienna
  • 2000 awarded Doctor rer. nat. techn.
  • 2000 University Assistant at the Dept. of Pathophysiology (formerly: Inst. of General and Experimental Pathology)
  • 2001 Principal Investigator of the SFB project “The role of cell-mediated immunity in Type I food allergies” by the Austrian Fonds zur Förderung Wissenschaftlicher Forschung Österreichs (FWF-F01807)
  • 2002 Venia docendi in Immunology at the Medical University of Vienna
  • 2002 Group Leader, Dept. of Pathophysiology, Center for Physiology and Pathophysiology, Medical University of Vienna, Austria
  • 2007 Managing Editor for International Archives of Allergy and Immunology
  • 2007 Principal investigator in the doctoral program “Inflammation and Immunity” by the Austrian Fonds zur Förderung Wissenschaftlicher Forschung Österreichs

Memberships:

  • European Academy of Allergology and Clinical Immunology (EAACI)
  • Austrian Society for Allergology and Immunology

Awards:

  • 2000 Thesis prize of the Austrian Society of Immunology and Allergology
  • 2001 3rd Allergopharma Award
  • 2002 Dr. Karl Schleinzer Award of the University of Natural Resources and Applied Life Sciences, Vienna
  • 2004 Special Award “Food allergy. New insight in cross-reactivity” of the Foundation for Allergy Research in Europe (FARE)
  • 2005 Allergopharma Award
  • 2005 Honorable Mentionship by the Pharmacia Allergy Research Foundation (PhARF)
  • 2005 Novartis Prize in Biology
  • 2006 International Award of the Pharmacia Allergy Research Foundation (PhARF)
  • 2006 Clemens von Pirquet Award of the Austrian  Society of Immunology and Allergology

Current research interests:

Cellular Immunology, Novel Concepts for Specific Type I Allergy Treatment, Food Allergy

Selected Publications:

  • Bohle, B., H. Schwihla, H. Z. Hu, R. Friedl-Hajek, S. Sowka, F. Ferreira, H. Breiteneder, C. A. Bruijnzeel-Koomen, R. A. de Weger, G. C. Mudde, C. Ebner, and F. C. Van Reijsen. Long-lived Th2 clones specific for seasonal and perennial allergens can be detected in blood and skin by their TCR-hypervariable regions. J Immunol 160:2022, 1998
  • Bohle, B., B. Jahn-Schmid, D. Maurer, D. Kraft, and C. Ebner. Oligodeoxynucleotides containing CpG motifs induce IL-12, IL-18 and IFN-gamma production in cells from allergic individuals and inhibit IgE synthesis in vitro. Eur J Immunol 29:2344, 1999
  • Bohle, B., B. Wagner, U. Vollmann, D. Buck, B. Niggemann, Z. Szepfalusi, G. Fischer, O. Scheiner, H. Breiteneder, and C. Ebner. Characterization of T cell responses to Hev b 3, an allergen associated with latex allergy in spina bifida patients. J Immunol 164:4393, 2000
  • Bohle, B., L. Orel, D. Kraft, and C. Ebner. Oligodeoxynucleotides containing CpG motifs induce low levels of TNF-alpha in human B lymphocytes: possible adjuvants for Th1 responses. J Immunol 166:3743, 2001
  • Bohle, B., A. Radakovics, B. Jahn-Schmid, K. Hoffmann-Sommergruber, G. F. Fischer, and C. Ebner. Bet v 1, the major birch pollen allergen, initiates sensitization to Api g 1, the major allergen in celery: evidence at the T cell level. Eur J Immunol 33:3303, 2003
  • Bohle, B., A. Breitwieser, B. Zwölfer, B. Jahn-Schmid, M. Sára, U. B. Sleytr and C. Ebner. A Novel Approach to Specific Allergy Treatment: The recombinant fusion protein of a bacterial cell surface (S-layer) protein and the major birch pollen allergen Bet v 1 (rSbsC-Bet v1) combines reduced allergenicity with immunomodulating capacity. J Immunol 172:6642, 2004
  • Bohle, B., A. Radakovics, D. Lüttkopf, S. Vieths and C. Ebner. Characterisation of the T cell response to the major hazelnut allergen, Cor a 1.04: evidence for a relevant T cell epitope not cross- reactive with homologous pollen allergens. Clin Exp Allergy 35:1392, 2005.

 

  • Schimek, E.M., B. Zwölfer, P. Briza, B. Jahn-Schmid, L. Vogel, S. Vieths, C. Ebner and B. Bohle. Gastrointestinal digestion of Bet v 1- homologous food allergens destroys their mediator-releasing but not T cell-activating capacity. J Allergy Clin Immunol 116:1327, 2005.

 

  • Jahn-Schmid, B., A. Radakovics, D. Lüttkopf, S. Scheurer, S. Vieths, C. Ebner and B. Bohle. Bet v 1142-156 is the dominant T cell epitope of the major birch pollen allergen and important for cross- reactivity with Bet v 1-related food allergens. J Allergy Clin Immunol 116:213, 2005.

 

  • Bohle, B., B. Zwölfer, A. Heratizadeh, B. Jahn-Schmid, Y. Dall Antonia, M. Alter, W. Keller, L. Zuidmeer, R. van Ree, T. Werfel and C. Ebner. Cooking birch pollen-related food: divergent consequences for IgE- and T cell-mediated reactivity in vitro and in vivo. J Allergy Clin Immunol 118:242, 2006

 

  • Kinaciyan, T., B. Jahn-Schmid, A. Radakovics, B. Zwölfer, C. Schreiber, J.N. Francis, C. Ebner and B. Bohle. Successful sublingual immunotherapy with birch pollen has limited effects on concomitant food allergy to apple and the immune response to the Bet v 1-homolog Mal d 1. J Allergy Clin Immunol, (DOI information: 10.1016/j.jaci.2006.11.010)