Accelerated dissociation of IgE-FcεRI complexes by disruptive inhibitors actively desensitizes allergic effector cells.
Eggel et al, J Allergy Clin Immunol, 2014, Vol. 133, No. 6.
Dr. Eggel obtained his PhD degree at University of Bern in Switzerland and following a year as Postdoctoral Fellow at the University of Stanford, he returned to Bern and is currently Group Leader at the Institute of Immunology. Over the years, he has received several recognitions for outstanding work in the fields of allergy and immunology.
In several publications the focus of has been on IgE/IgE-receptor interactions. The awarded publication describes the action of a new class of IgE inhibitors with therapeutic potential acting by suppression of the allergic response of effector cells from sensitised individuals.Thereby this paper provides new knowledge as well as points at potential applications in present and future diagnostic and therapeutic regimens.